Using Botox for Migraine and Headache Treatment, Phase II Studies Part 3

[PLATFORM SESSION III: SATURDAY JUNE 25TH, 3:00-4:30 PM] (Please see appraisal lint below.) "Efficacy of Prophylactic Treatment beside Botulinum Toxin Type A enclosed with Migraineurs with Chronic Daily Headache Overusing Acute Headache Pain Medications," Joel R. Saper, MD, FACP, FAAN, et al.

[PLATFORM SESSION II, #ABH0163: SATURDAY JUNE 25TH, 12:00-2:00 PM] Summary: Between-group difference (BOTOX® vs. placebo) by the side of the one-time efficacy gauge (i.e., miserable revision from baseline in the cipher of headache-free days at daytime 180) subsist out not conquer statistical gravity. However, hold an important effect differences compare to placebo be demonstrated on other knob, clinically smart efficacy measures, together with a shoot less in the frequency of headache point, a decrease of at lowest possible 50% in headache days, and a decrease in acute medication spend (Frishberg et al).

-- Differences on key efficacy measures in favor of BOTOX® were even more evident in a subgroup analysis of patients who were not taking other prophylactic medication to reckless outlay their headache (Dodick et al), and were more robust dogmatic in a further subanalysis of these patients who were overusing acute cramp medication (Saper et al). These latter grades be extremely meaningful since the overuse of pain medication in favour of headache be associated with upholding of continual headache and significant disability.

-- Treatment with BOTOX® be well-tolerated.

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